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Atovaquone/Proguanil *Travel Assessment Form required*

Atovaquone/Proguanil *Travel Assessment Form required*

SKU: 364215375135191

Generic Atovaquone/Proguanil



    **Please ensure the online assessment form is completed prior to purchasing this product. This is to ensure it is clinically appropriate for you. Your assessment form will be reveiwed on the day of your purchase. If suitable, the medication will be dispatched and you will be notified. If this is not completed OR the medication is clinically inapropriate your order placed will be cancelled and your money will be refunded. A Healthcare professional will be in touch to recommend an alternative**


    What is Atovaquone and Proguanil?

    Atovaquone (250mg) and Proguanil (100mg) is a combination drug and each component stops the P.falciparum parasite from reproducing in the blood. It is used as a preventative method against malaria from bites from mosquitoes infected with this parasite.

    Stronger doses of the drug are used to treat uncomplicated malaria from the same parasite.


    Who is at risk of malaria?

    Malaria is a tropical disease carried by mosquitoes in infected areas, and is common in areas such as Southern Asia, Africa, and South America. Before travelling to these climates, it is important to check the malaria risk for the specific location and time of year you are visiting. Complete the travel assessment form for advice.

    People who previously built up immunity by living in malarial areas can lose that immunity over time. The recommended tablets for an area can change from time-to-time.

    Children and women who are pregnant or breastfeeding are at increased risks, including severe and fatal malaria.

    See a doctor immediately if you get flu-like symptoms such as a high temperature, headache, body aches, shivering and tiredness after leaving a malaria risk area for up to one year, as this may indicate a malaria infection.


    Why Atovaquone/Proguanil?

    Atovaquone/Proguanil is one of many anti-malarial drugs that can be prescribed but is particularly effective in high-risk areas where resistance to chloroquine, which targets the same P.falciparum parasite, is prevalent. Its simple dosage means it is suitable for last-minute holidays and trips of shorter duration.

    Complete our clinical assessment form and a clinician will be in touch with their recommendation.


    How to take Atovaquone/Proguanil

    After consultation with a doctor, detailing the specifics of your trip, your Atovaquone/Proguanil prescription needs to be started one to two days before entering an area with malaria risk. Take one tablet every day during your stay and for seven days after leaving the area.

    Take the tablet at the same time once a day with food or a milky drink. For the medication to be effective, and to prevent resistance, the whole course of tablets must be completed.

    If you forget to take a dose just take your next dose as soon as you remember. Then continue your treatment as before.


    How effective is it?

    No anti-malarial medication is 100% effective and preventative measures should be taken to decrease the risk of being bitten in high-risk areas. Cover exposed skin, especially during and after dusk, use an insect repellent and mosquito nets at night.


    What are the side effects of Atovaquone/Proguanil?

    All medication affects patients individually, with some possible side effects being more common than others. Atovaquone/Proguanil is very well tolerated compared with other antimalarials. A full list of side effects can be found in the manufacturer's patient information leaflet (PIL) supplied with Atovaquone/Proguanil tablets.

    Common side effects (affecting more than 1 in 10 people) include headaches, nausea, vomiting, diarrhoea and abdominal pain. These side effects can often be alleviated by taking Atovaquone/Proguanil with food or a milky drink.

    Less common side effects (affecting up to 1 in 10 people) include loss of appetite, coughing, dizziness, fever, rash or itching, insomnia, or abnormal dreams, and anaemia.

    Uncommon side effects (affecting up to 1 in 100 people) include anxiety, palpitations, swelling and redness of the mouth, hair loss, and hives. Other rare side effects are listed in the patient information leaflet.

    What should I do if I experience side effects from Atovaquone/Proguanil?

    • Try to persevere with the medication.
    • Take it regularly as directed, with food or a milky drink.
    • Stick to plain, bland food stuffs.
    • You can treat nuisance side effects with commonly used medicines. Headache can be treated with paracetamol for example. For nausea/vomiting, try an anti-sickness medication such as promethazine.
    • Do not stop taking your malaria prophylaxis unless you can possible help it.
    • If you are sick (vomit) within 1 hour of taking your Atovaquone/Proguanil tablet, take another dose straight away.
    • If you feel dizzy, do not drive or operate machinery.
    • If you are worried you have had a serious side effect from Atovaquone/Proguanil you must report this to your doctor.
    • Adverse reactions should be reported on the Yellow Card Scheme.

    Allergic reactions after taking Atovaquone/Proguanil

    If you have any symptoms or signs suggestive of an acute allergic reaction (anaphylaxis), you must get medical help immediately.

    Symptoms/signs of an acute allergic reaction include:

    • Difficulty breathing, tight chest, wheezing.
    • Swelling of the face, eyelids, lips, tongue, or other parts of the body.
    • Skin rash - urticaria/hives. Usually treated with anti-histamine.
    • Confusion, collapse, unconsciousness.

    For more information see NHS - Anaphylaxis.


    Who should not take Atovaquone/Proguanil?

    You will be required to complete an assessment questionnaire to determine your suitability for anti-malarial medication. You should not take Atovaquone/Proguanil without further consultation with your GP if you:

    • Are allergic to atovaquone or proguanil
    • Are pregnant or breastfeeding or intend to be during your trip or two months after
    • Have been diagnosed with liver disease or severe kidney disease
    • Have epilepsy or seizures
    • Are currently taking:
      • warfarin and other medicines to thin the blood
      • metoclopramide, used to treat nausea and vomiting
      • the antibiotics, tetracycline, rifampicin, or rifabutin
      • efavirenz or certain highly active protease-inhibitors used to treat HIV
      • etoposide used to treat cancer

    If you start taking any other medicines whilst taking Atovaquone/Proguanil speak to your doctor or pharmacist.

    Atovaquone/Proguanil Adult tablets are recommended for preventing malaria in people over 40kg. Malarone Paediatric tablets are available for children from 11kg on prescription from GPs, or from specially trained pharmacists.


    For more information on Atovaquone/Proguanil, click here

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